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Mucosal and systemic antibody responses and protection induced by a prime/boost rotavirus-DNA vaccine in a gnotobiotic pig model

✍ Scribed by Lijuan Yuan; Marli S.P. Azevedo; Ana M. Gonzalez; Kwang-il Jeong; Trang Van Nguyen; Peggy Lewis; Cristiana Iosef; John E. Herrmann; Linda J. Saif


Book ID
116958029
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
330 KB
Volume
23
Category
Article
ISSN
0264-410X

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Systemic and intestinal antibody respons
✍ Cristiana Iosef; Kyeong-Ok Chang; Marli S.P. Azevedo; Linda J. Saif πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 148 KB

Antibody responses to the Wa human rotavirus (HRV) nonstructural protein NSP4, a viral enterotoxin, were evaluated in neonatal gnotobiotic (Gn) pigs. Gn pigs were inoculated orally with one dose of 10(5) fluorescent focus units (FFU) of virulent Wa HRV (HRV-V), to mimic natural infection, or with th