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Mucosal administration of an altered CII263-272 peptide inhibits collagen-induced arthritis by suppression of Th1/Th17 cells and expansion of regulatory T cells

✍ Scribed by Jinxia Zhao; Ru Li; Jing He; Jinxia Shi; Li Long; Zhanguo Li


Publisher
Springer
Year
2008
Tongue
English
Weight
473 KB
Volume
29
Category
Article
ISSN
0172-8172

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## Abstract ## Objective To prevent and treat experimental arthritis via nasal administration of an altered peptide ligand (APL) from the major arthritogenic epitope in adjuvant‐induced arthritis (AIA) and to explore the mechanisms involved. ## Methods Peptides were administered nasally before a