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Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome

✍ Scribed by Sarbani Ghosh-Laskar; Vedang Murthy; Tabassum Wadasadawala; Jaiprakash Agarwal; Ashwini Budrukkar; Nikhilesh Patil; Shubhada Kane; Devendra Chaukar; Prathamesh Pai; Pankaj Chaturvedi; Anil D'Cruz

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
340 KB
Volume
33
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

The purpose of this study was to identify the prognostic factors affecting the outcome in patients with mucoepidermoid carcinoma (MEC) of the parotid gland.

Methods

A total of 113 patients with MEC who were treated between 1993 and 2002 were analyzed.

Results

At median follow‐up of 49 months (range, 1–143 months), disease‐free survival (DFS) at 5 and 10 years was 84.6 and 84.6%, 80.7% and 67.3%, and 52.5% and 35.0% for low‐grade, intermediate‐grade, and high‐grade tumors, respectively. Five‐year and 10‐year overall survival was 96.8% for low‐grade tumors; 94.1% and 82.4%, respectively, for intermediate‐grade tumors; and 73.3% for high‐grade tumors. High‐grade tumors and lymph node cancer‐positive neck tumors strongly predicted poor locoregional control and DFS, while close or positive cut margins showed a trend toward poorer outcomes.

Conclusion

Histologic grade is the most important factor affecting outcome in parotid MEC. Adjuvant radiotherapy is recommended for high‐grade tumors and should be tailored according to the expected risk of recurrence for low‐grade and intermediate‐grade tumors. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

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