Mucoepidermoid carcinoma of the major salivary glands : Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria
✍ Scribed by Robert K. Goode; Paul L. Auclair; Gary L. Ellis
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 305 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
METHODS.
Clinical data and 15 histopathologic features were compared in 4 patient groups based on outcome after initial treatment. The outcome groups were 1) 2 Department of Oral and Maxillofacial Patholsurvival without disease, 2) survival with tumor recurrence only, 3) survival with ogy, Naval Dental School, National Naval Dental Center, Washington, DC.
metastasis, and 4) death related to tumor. A numeric score was assigned to each unfavorable histopathologic feature. Low grade tumors had scores of 0-4. Interme-3 Department of Veterans Affairs Special Referdiate grade tumors scored 5 or 6. High grade tumors had scores higher than 6. ence Laboratory for Pathology, Armed Forces
RESULTS.
Most patients (75%) were tumor free after the initial treatment. Twenty-Institute of Pathology, Washington, DC.
one patients (9%) had local recurrence only, 12 (5%) demonstrated metastasis and survived, and 25 patients (11%) died of their disease.
CONCLUSIONS.
Clinical features associated with metastasis or death were more advanced age, tumor size, and preoperative symptoms. Histopathologic features that correlated with poor outcome were cystic component less than 20%, 4 or more mitotic figures per 10 high-power fields, neural involvement, necrosis, and anaplasia. All five of these histopathologic features demonstrated statistical prognostic significance when parotid gland tumors from Groups 1 and 4 were compared (P õ 0.001). The point-based grading system demonstrated a statistically significant correlation with outcome for parotid tumors but not for submandibular tumors.
Information contained in this manuscript was
The authors' findings indicate that patients with tumors of equal histopathologic presented at an Armed Forces Institute of Pagrade have a better prognosis when their tumors are in the parotid gland than thology (AFIP) professional staff conference when their tumors are in the submandibular gland. Six of eight submandibular and in lectures on salivary gland pathology tumors that metastasized or resulted in death were low grade lesions, and none sponsored by the AFIP.
were high grade.