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Mucoadhesive and Elastic Films Based on Blends of Chitosan and Hydroxyethylcellulose

✍ Scribed by Kun Luo; Jingbo Yin; Olga V. Khutoryanskaya; Vitaliy V. Khutoryanskiy

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
436 KB
Volume
8
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 °C leads to partial cross‐linking of the polymers and formation of water‐insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.

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