✦ LIBER ✦

Mucins: Structure, function, and associations with malignancy

✍ Scribed by Peter L. Devine; Ian F. C. McKenzie

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 884 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140909

No coin nor oath required. For personal study only.

✦ Synopsis

Mucins are a family of high molecular weight, highly glycosylated glycoproteins found in the apical cell membrane of human epithelial cells from the mammary gland, salivary gland, digestive tract, respiratory tract, kidney, bladder, prostate, uterus and rete testis. Increased synthesis of the core protein and alterations in the carbohydrates attached to these glycoproteins are believed to play important roles in the function and proliferation of tumour cells. Aberrant glycosylation leads not only to the production of novel carbohydrate structures, but also to the exposure of the core peptide. These novel epitopes may be candidates for diagnosis or therapy, by using either synthetic mucin fragments as vaccines, or monoclonal antibody-based reagents which detect these structures.

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