## Background: The human mismatch repair (mmr) gene hmsh2 (human muts homolog-2) is a dna repair gene that has been reported to be mutated in 40% of hereditary nonpolyposis colon cancer (hnpcc) kindreds and a small percentage of sporadic tumors. hnpcc is a cancer predisposition syndrome with an inc
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Mucin profiles and potential for malignancy of human colorectal adenomatous polyps
โ Scribed by G. Griffioen; F. T. Bosman; H. W. Verspaget; P. A. F. de Bruin; I. Biemond; C. B. H. W. Lamers
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 444 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Matrilysin mRNA has been reported to be overexpressed in colorectal cancer. The aim of this study was to evaluate the enzyme activity of this protein d