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MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells

✍ Scribed by Ponnusamy, M P; Lakshmanan, I; Jain, M; Das, S; Chakraborty, S; Dey, P; Batra, S K


Book ID
109972604
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
155 KB
Volume
29
Category
Article
ISSN
0950-9232

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## Abstract In the current study, we investigated the mechanism relating downregulation of mitogen‐activated protein kinase kinase 4 (MKK4) expression to development of ovarian cancer. Over‐expression of the MKK4 gene in TOV‐21 G cells, a line with homozygous deletion of MKK4, resulted in morpholog