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MTHFRC677T and A1298C polymorphisms are risk factors for Down’s syndrome in Indian mothers

✍ Scribed by Amit Kumar Rai; Satya Singh; Stuti Mehta; Ashok Kumar; L. K. Pandey; Rajiva Raman


Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
219 KB
Volume
51
Category
Article
ISSN
1435-232X

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Evaluation of C677T and A1298C polymorph
✍ Ana Paula Carneiro Brandalize; Eliane Bandinelli; Pollyanna Almeida dos Santos; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This case–control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola