The Czech Republic has one of the highest incidences of colorectal cancer (CRC) in the world. To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A(1)>A(2), rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and rs1059234:C
✦ LIBER ✦
MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case–control study from the Czech Republic
✍ Scribed by Barbara Pardini; Rajiv Kumar; Alessio Naccarati; Rashmi B. Prasad; Asta Forsti; Veronika Polakova; Ludmila Vodickova; Jan Novotny; Kari Hemminki; Pavel Vodicka
- Book ID
- 116759881
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 167 KB
- Volume
- 721
- Category
- Article
- ISSN
- 1383-5718
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## Abstract Cyclin D1 (CCND1) and E‐cadherin (CDH1) have been shown to be important genes of the β‐catenin/LEF pathway that is involved in colorectal carcinogenesis. However, epidemiological studies on relationship between genetic variants of these two genes and colorectal cancer (CRC) have shown i