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MspI polymorphic site in intron 22 of the factor VIII gene in the Japanese population

✍ Scribed by Hiroshi Inaba; Michio Fujimaki; Haig H. Kazazian; Stylianos E. Antonarakis

Publisher: Springer
Year: 1990
Tongue: English
Weight: 112 KB
Volume: 84
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00208947

No coin nor oath required. For personal study only.

✦ Synopsis

A novel MspI DNA polymorphic site has been found in intron 22 of the human factor VIII gene. This site is informative almost exclusively in the Japanese population (heterozygosity 0.45) and will be of considerable importance in carrier detection and prenatal diagnosis of hemophilia A in this population.

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