Mrp2 Is Essential for Estradiol-17β(β-d -glucuronide)–Induced Cholestasis in Rats
✍ Scribed by Liyue Huang; Johan W. Smit; Dirk K. Meijer; Mary Vore
- Book ID
- 111721270
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 129 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
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Estradiol-l7&~-glucuronide (E-l7G), a metabolite of natural estrogen, is a potent cholestatic agent in uivo. We, therefore, studied the mechanisms of E-17G cholestasis using in vitro perfused rat liver system. Furthermore, since it has been postulated that sodium taurocholate (TC) may interfere with
The endogenous estradiol metabolite estradiol 17beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance-associated protein 2 (Mrp2, Abcc2) and their associated loss