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MRP genes in the hepatic transport of a new MRI contrast agent

✍ Scribed by Cristina Fernetti; Vito Lorusso; Lorella Pascolo; Massimo Visigalli; Simona Ramponi; Claudio Tiribelli


Book ID
118565421
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
115 KB
Volume
36
Category
Article
ISSN
0168-8278

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We have studied the hepatic transport of Fe(III)-N-(3-phenylglutaryl)desferrioxamine B (Fe-PGDF). Using 59Fe-PGDF in biliary cannulated rats we have shown that 32 +/- 2% of an iv bolus dose was excreted into the bile. In animals pretreated with a saturating dose of taurocholate, oxyphenonium, or bro