Mri quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa3 oxidation state

✍ Scribed by R. A. Kline; W. G. Negendank; L. E. Mccoy; M. Lester; R. Berguer

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 339 KB
• Volume: 13
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910130215

✦ Synopsis

Abstract

^1^H MRI permits detection of edema in the brain. In a middle cerebral artery stroke model in the cat, we found a significant correlation between an edema index based on MRI and a sensitive metabolic index of ischemia, the in vivo oxidation status of mito‐chondrial cytochrome aa~3~ determined by near‐infrared reflectance spectrophotometry (r= −0.70, α = 0.001). This result suggests that a simple, noninvasive study using MRI can provide an index of the extent of ischemic damage in an experimental acute stroke model.