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MRI-guided focused ultrasound surgery in the brain: Tests in a primate model

โœ Scribed by Nathan McDannold; Mark Moss; Ron Killiany; Douglas L. Rosene; Randy L. King; Ferenc A. Jolesz; Kullervo Hynynen

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
869 KB
Volume
49
Category
Article
ISSN
0740-3194

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โœฆ Synopsis

Abstract

MRIโ€guided focused ultrasound was tested in the brains of rhesus monkeys. Locations up to 4.8 cm deep were targeted. Focal heating was observed in all cases with MRIโ€derived temperature imaging. Subthreshold heating was observed at the focus when the ultrasound beam was targeted with low power sonications, and in the ultrasound beam path during highโ€power exposures. Lethal temperature values and histologically confirmed tissue damage were confined to the focal zone (e.g., not in the ultrasound beam path), except when the focus was close to the bone. In that case, damage to the neighboring brain tissue was observed. Focal lesions were observed on histological examination and, in some cases, in MR images acquired immediately after the ultrasound exposures. The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain. Magn Reson Med 49:1188โ€“1191, 2003. ยฉ 2003 Wileyโ€Liss, Inc.

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