MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer

✍ Scribed by P. V. Prasad; D. Burstein; R. R. Edelman

• Book ID: 102533261
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 468 KB
• Volume: 30
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910300219

✦ Synopsis

Abstract

We propose a new magnetic resonance imaging (MRI) technique that is sensitive to myocardial tissue perfusion that obviates the use of an extrinsic contrast agent. Significant advantages of such a technique are that it avoids accumulation of contrast agent when repeated studies are performed on the same subject and that it is completely noninvasive. The method makes use of a combination of magnetization transfer (MT) and T~1~^sut^ (measured spin‐lattice reiaxation time in the presence of MT) weighting. in this Communication, we present observations from experiments with an isolated rat heart model that demonstrate increase of MT‐weighted signal Intensity and T~1~^sut^ with flow. Also included are data showing that these effects can be made synergistic for enhancing the sensitivity to perfusion. We have observed about a 3% change in MT‐weighted intensity end up to 10% change in MT__T__~1~^sut^‐weighted intensity for a change of 1 ml/min in global flow rate.