MRI and quantitative autoradiographic studies following bolus injections of unlabeled and 14C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants

The MRI-measured arterial input function

The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots

✍ Tavarekere N. Nagaraja; Kishor Karki; James R. Ewing; George W. Divine; Joseph D 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB

## Abstract The hypothesis that the arterial input function (AIF) of gadolinium‐diethylenetriaminepentaacetic acid injected by intravenous bolus and measured by the change in the __T__~1~‐relaxation rate (Δ__R__~1~; __R__~1~ = 1/__T__~1~) of superior sagittal sinus blood (AIF‐I) approximates the AI