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Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication

✍ Scribed by Sanchita Krishna; Brant M. Wagener; Hui Ping Liu; Yi-Chen Lo; Rosa Sterk; John H.J. Petrini; Jac A. Nickoloff

Book ID
116410636
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
983 KB
Volume
6
Category
Article
ISSN
1568-7864

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## Abstract Cells, which lacked the activity of the nuclease Artemis, retained approximately 10% of unrepaired double strand breaks (DSBs) at later timepoints after ionizing radiation. Ionizing radiation induced hyperphosphorylation of Artemis mainly by ATM and in ATM deficient cells to a minor ext