Abstract
Purpose
To establish normative metabolite ratios throughout the newborn brain using threeโdimensional (3D) MR spectroscopic imaging (MRSI).
Materials and Methods
MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. Fiftyโfive newborn subjects (28.4 ยฑ 2.6 weeks postconception age at birth, 34.1 ยฑ 3.1 weeks postconception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (neuromotor score = 0, mental development index score > 85) at age 12 months.
Results
The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions.
Conclusion
Brain metabolites can be obtained through in vivo 3D MRSI and used to monitor newborn brain maturation. J. Magn. Reson. Imaging 2011;33:306โ311. ยฉ 2011 WileyโLiss, Inc.