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MR-spectroscopic findings in juvenile-onset Huntington's disease

✍ Scribed by Norman C. Reynolds; Robert W. Prost; Leighton P. Mark; Suja A. Joseph

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 540 KB
Volume: 23
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22245

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✦ Synopsis

Abstract

Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton‐MR‐spectroscopy (^1^H‐MRS) profiles of the putamen. Despite clinical variability, the predominate ^1^H‐MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine. © 2008 Movement Disorder Society

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