MR imaging of blood oxygenation-dependent changes in focal renal ischemia and transplanted liver tumor in rat

✍ Scribed by Vladimir S. Vexler; Alexander J. S. De Crespigny; Michael F. Wendland; Ryonei Kuwatsuru; Andreas Mühler; Robert C. Brasch; Michael E. Moseley

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 824 KB
• Volume: 3
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880030310

✦ Synopsis

Abstract

The potential of using fast magnetic resonance (MR) imaging in conjunction with apnea‐induced blood deoxygenation for the noninvasive monitoring of relative perfusion in the rat abdomen has been studied with two experimental models: glycer‐ol‐induced focal renal ischemia and transplanted liver tumor. Gradient‐echo echo‐planar imaging (GRE‐EPI) (TE of 20 msec at 2 T) of liver and kidney was performed before, during, and after a 60‐second apnea episode and then was followed in the same rat by contrast‐enhanced (a) GRE‐EPI and (b) T1‐weighted spin‐echo imaging (TR msec/TE msec = 200/6) with polylysine‐(gadolmium‐DTPA [diethylenetriaminepentaacetic acid]). The results indicate that a noninvasive vascular challenge due to apnea can be used for the detection of focal tissue perfusion abnormalities in rat kidney and liver tumor.