MR Imaging detection of cerebral metastases with a single injection of high-dose gadoteridol

✍ Scribed by Val M. Runge; John W. Wells; Kevin L. Nelson; Pam M. Linville

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 679 KB
• Volume: 4
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880040509

✦ Synopsis

Abstract

The utility of a single high‐dose (0.3 mmol/kg) injection of gadoteridol, a gadolinium chelate, in the detection of brain metastases on magnetic resonance images was studied. Patients (n = 29) with a high suspicion for brain metastases at clinical examination and by history were imaged on two occasions–separated by more than 24 hours and less than 7 days–with a 0.1 mmol/kg contrast agent dose used for the first study and a 0.3 mmol/kg dose for the second. In patients (n = 15) with confirmed brain metastases by clinical, radiologic, and/or histologic criteria, 40 lesions were detected at the 0.3 mmol/kg dose by a single reader blinded to contrast agent dose, compared with 33 lesions at 0.1 mmol/kg, a 21% increase. Three of 15 patients (20%) demonstrated an increase in the number of lesions detected at the higher dose. Region‐of‐interest analysis of signal intensity measurements showed that lesion contrast (relative to normal brain) improved from 54% at 0.1 mmol/kg to 92% at 0.3 mmol/kg. A 0.3 mmol/kg dose of gadoteridol, administered in a single injection, permits identification of brain metastases not detected at 0.1 mmol/kg. Such information can influence the choice of therapy.