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MR flow mapping of dobutamine-induced changes in diastolic heart function

✍ Scribed by Bernard P. Paelinck; Hildo J. Lamb; Jeroen J. Bax; Ernst E. van der Wall; Albert de Roos

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
208 KB
Volume
19
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during β‐adrenergic stimulation.

Materials and Methods

Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast‐field echo (FFE) with a spatial resolution of 2.7 × 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 μg/kg/minute).

Results

Stroke volume increased from a median of 99 mL (range: 68–142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87–180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second [433–497 mL] to 651 mL/second [496–1096 mL/second]) (P < 0.05) and atrial (A) peak filling rate (238 mL/second [183–352 mL/second] to 341 mL/second [230–538 mL/second]) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation.

Conclusion

Conventional free breathing FFE has the ability to measure the effects of β‐adrenergic stimulation on left ventricular filling. J. Magn. Reson. Imaging 2004;19:176–181. © 2004 Wiley‐Liss, Inc.

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