MR elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure–volume model in a left ventricular model of the heart
✍ Scribed by Arunark Kolipaka; Kiaran P. McGee; Philip A. Araoz; Kevin J. Glaser; Armando Manduca; Anthony J. Romano; Richard L. Ehman
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 464 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Magnetic resonance elastography (MRE) measurements of shear stiffness (μ) in a spherical phantom experiencing both static and cyclic pressure variations were compared to those derived from an established pressure–volume (P‐V)‐based model. A spherical phantom was constructed using a silicone rubber composite of 10 cm inner diameter and 1.3 cm thickness. A gradient echo MRE sequence was used to determine μ within the phantom at static and cyclic pressures ranging from 55 to 90 mmHg. Average values of μ using MRE were obtained within a region of interest and were compared to the P‐V‐derived estimates. Under both static and cyclic pressure conditions, the P‐V‐ and MRE‐based estimates of μ ranged from 98.2 to 155.1 kPa and 96.2 to 150.8 kPa, respectively. Correlation coefficients (R^2^) of 0.98 and 0.97 between the P‐V and MRE‐based estimates of shear stiffness measurements were obtained. For both static and cyclic pressures, MRE‐based measures of μ agree with those derived from a P‐V model, suggesting that MRE can be used as a new, noninvasive method of assessing μ in sphere‐like fluid‐filled organs such as the heart. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.