MP31-06 DIET INDUCED ALTERATION OF FATTY ACID SYNTHASE IS INVOLVED IN PROSTATE CANCER PROGRESSION

Epigallocatechin-3-gallate is a potent n

Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells

✍ Koen Brusselmans; Ellen De Schrijver; Walter Heyns; Guido Verhoeven; Johannes V. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 409 KB 👁 1 views

Chemical inhibitors of fatty acid synthase (FAS) inhibit growth and induce apoptosis in several cancer cell lines in vitro and in tumor xenografts in vivo. Recently the green tea component epigallocatechin-3-gallate (EGCG) was shown to act as a natural inhibitor of FAS in chicken liver extracts. Her