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M.P.1.06 A novel mutation in the mitochondrial ND3 gene causing Leigh syndrome with late-onset neurological decline

✍ Scribed by M. Tchikviladzé; P. Laforêt; B. Eymard; F. Delbos; S. Filaut; A. Lombès; C. Jardel


Book ID
116792881
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
47 KB
Volume
17
Category
Article
ISSN
0960-8966

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## Abstract Defects in NADH:ubiquinone oxidoreductase (complex I), the largest complex of the mitochondrial respiratory chain, account for most cases of respiratory chain deficiency in human. Complex I contains at least 45 subunits, 7 of which are encoded by mitochondrial DNA (mtDNA). Here we repor