Movement parameters that distinguish between voluntary movements and levodopa-induced dyskinesia in Parkinson’s disease
✍ Scribed by Noël L.W Keijsers; Martin W.I.M Horstink; Stan C.A.M Gielen
- Book ID
- 114156204
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 601 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0167-9457
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## Abstract Long‐term treatment of human Parkinson's disease with levodopa or dopamine agonists is often complicated by the appearance of abnormal involuntary movements (dyskinesias) that are extremely difficult to control. Little is known of the cause, pathophysiological mechanisms, or possible st
Previous studies in the MPTP-lesioned primate model of Parkinson's disease have demonstrated that alpha(2) adrenergic receptor antagonists such as idazoxan, rauwolscine, and yohimbine can alleviate L-dopa-induced dyskinesia and, in the case of idazoxan, enhance the duration of anti-parkinsonian acti