Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development

✍ Scribed by Akihito Yamamoto; Caroline Kemp; Daniel Bachiller; Douglas Geissert; E.M. De Robertis

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 526 KB
• Volume: 27
• Category: Article
• ISSN: 1526-954X
• DOI: 10.1002/1526-968x(200006)27:2<49::aid-gene10>3.0.co;2-7

✦ Synopsis

Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During earlyto mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile. genesis 27:49 -57, 2000.