Mouse p53 inhibits SV40 origin-dependent DNA replication
β Scribed by Braithwaite, Antony W.; Sturzbecher, Horst-Werner; Addison, Christine; Palmer, Colin; Rudge, Karran; Jenkins, John R.
- Book ID
- 109750698
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 324 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/329458a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian oneβcell embryo is unique becau
increasing evidence has supported the concept that many of the enzymes and factors involved in the replication of mammalian DNA function together as a multiprotein complex. We have previously reported on the partial purification of a multiprotein form of DNA polymerase from human HeLa cells shown to
## Abstract Epidemiologic investigations demonstrated that arsenite exposure increases the risk of various human cancers, including skin, lung, bladder, and kidney cancers. However, oral administration of arsenite alone has failed to induce tumors in animal models, suggesting that arsenic may act t