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Mouse Models of Tumor Development in Neurofibromatosis Type 1 

✍ Scribed by Cichowski, K.

Book ID
121161906
Publisher
American Association for the Advancement of Science
Year
1999
Tongue
English
Weight
761 KB
Volume
286
Category
Article
ISSN
0036-8075

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## Abstract The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production of inactive rasGDP, with wide‐ranging effects on p21ras pathw

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The two main peripheral nerve sheath tumors found in patients with neurofibromatosis, type 1 (NF1), are neurofibroma, a benign tumor, and malignant peripheral nerve sheath tumor (MPNST). The tumors are related in that most MPNSTs are thought to arise by malignant transformation of neurofibromas. Suc