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Mouse models of mitochondrial DNA defects and their relevance for human disease

✍ Scribed by Tyynismaa, Henna; Suomalainen, Anu

Book ID
109851162
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
335 KB
Volume
10
Category
Article
ISSN
1469-221X

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## Abstract NADH‐ubiquinone oxidoreductase (complex I) is a large, multimeric enzyme complex involved in the generation of ATP by oxidative phosphorylation. Complex I is comprised of 45 subunits which must be assembled together in a coordinated process to form the mature holoenzyme. In recent years