Mouse models of autism spectrum disorders: The challenge for behavioral genetics
โ Scribed by Sheryl S. Moy; Jessica J. Nadler; Terry R. Magnuson; Jacqueline N. Crawley
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 170 KB
- Volume
- 142C
- Category
- Article
- ISSN
- 1552-4868
No coin nor oath required. For personal study only.
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Biological and positional evidence supports the involvement of the GAD1 and distal-less homeobox genes (DLXs) in the etiology of autism. We investigated 42 single nucleotide polymorphisms in these genes as risk factors for autism spectrum disorders (ASD) in a large family-based association study of
## Abstract ## BACKGROUND Neural tube defects (NTDs) are congenital malformations arising mostly from incomplete neural tube closure during early embryogenesis. Most NTDs in humans have a complex etiology, with involvement of both genetic and environmental factors. More than 100 mouse models for h