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Mouse models for human familial adenomatous polyposis

✍ Scribed by Raju Kucherlapatia; Diana P Lin; Winfried Edelmann

Book ID
112265029
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
196 KB
Volume
11
Category
Article
ISSN
1044-579X

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In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were f

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## Abstract Familial adenomatous polyposis (FAP) is a genetic disorder transmitted in an autosomal dominant pattern. One‐half of members of an affected family will carry the gene, and all carriers will succumb to colon cancer or extracolonic manifestations if not detected and treated early. When th