Gene regulation by IL-1β independent of
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Ralph Andre; Jonathan G. Moggs; Ian Kimber; Nancy J. Rothwell; Emmanuel Pinteaux
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Article
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2006
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John Wiley and Sons
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English
⚖ 276 KB
## Abstract Interleukin‐1 (IL‐1) is a key pro‐inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL‐1α and IL‐1β, bind to a single known functional type‐1 IL‐1 receptor (IL‐1RI) that associates wit