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Mouse IgG1 heterogeneity: Variable binding of monoclonal IgG1 antibodies to protein a-sepharose

โœ Scribed by C.L. Villemez; M.A. Russell; P.L. Carlo


Book ID
119089417
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
587 KB
Volume
21
Category
Article
ISSN
0161-5890

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Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental