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Mouse Group X Secretory Phospholipase A2 Induces a Potent Release of Arachidonic Acid from Spleen Cells and Acts as a Ligand for the Phospholipase A2 Receptor

โœ Scribed by Yasuhide Morioka; Akihiko Saiga; Yasunori Yokota; Noriko Suzuki; Minoru Ikeda; Takashi Ono; Kazumi Nakano; Noriko Fujii; Jun Ishizaki; Hitoshi Arita; Kohji Hanasaki


Book ID
115568381
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
498 KB
Volume
381
Category
Article
ISSN
0003-9861

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Glutamate signalling and secretory phosp
โœ Elena B. Rodriguez de Turco; Fannie R. Jackson; Mark A. DeCoster; Miriam Kolko; ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 249 KB

The lipid mediators generated by phospholipases A(2) (PLA(2)), free arachidonic acid (AA), eicosanoids, and platelet-activating factor, modulate neuronal activity; when overproduced, some of them become potent neurotoxins. We have shown, using primary cortical neuron cultures, that glutamate and sec