Mouse Balb/c3T3 cell mutant with low epidermal growth factor receptor activity: Induction of stable anchorage-independent growth by transforming growth factor β

Role of Smad3, acting independently of t

Role of Smad3, acting independently of transforming growth factor-β, in the early induction of Wnt-β-catenin signaling by parathyroid hormone in mouse osteoblastic cells

✍ Yoshifumi Inoue; Lucie Canaff; Geoffrey N. Hendy; Itoko Hisa; Toshitsugu Sugimot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract Parathyroid hormone (PTH) exerts an anabolic action on bone but the mechanisms are incompletely understood. We showed previously that PTH interacts with the canonical Wnt‐β‐catenin signaling pathway via the transforming growth factor (TGF)‐β signaling molecule, Smad3, to modulate osteob