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Motuporin, A Potent Protein Phosphatase Inhibitor Isolated from the Papua New Guinea Sponge Theonella swinhoei Gray

✍ Scribed by E.Dilip de Silva; David E. Williams; Raymond J. Andersen; Heide Klix; Charles F.B. Holmes; Theresa M. Allen

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 331 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)91674-5

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✦ Synopsis

A b&act: Motuporin (I), a cyclic pcntapeptide that is a potent protein phosphatase-1 inhibitor and cylotoxin, has been isolated from the marine sponge Theonella swinhoei collected in Papua New Guinea. The structure of motuporjn was elucidafed by spectroscopic anaIysis and chemical degradation.

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