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Motor neuron dysfunction in a mouse model of ALS: Gender-dependent effect of P2X7 antagonism

✍ Scribed by Cervetto, Chiara; Frattaroli, Daniela; Maura, Guido; Marcoli, Manuela

Book ID: 120226147
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 792 KB
Volume: 311
Category: Article
ISSN: 0300-483X
DOI: 10.1016/j.tox.2013.04.004

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## Abstract Amyotrophic lateral sclerosis (ALS) is a late‐onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effec