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Motor nerve biopsy in severe Guillain-Barré syndrome

✍ Scribed by Dr Susan M. Hall; Richard A. C. Hughes; Penny F. Atkinson; Ian McColl; Andrew Gale

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
1018 KB
Volume
31
Category
Article
ISSN
0364-5134

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✦ Synopsis

We undertook a biopsy of a terminal branch of the musculocutaneous nerve in a man with severe Guillain-Barre syndrome and very small distally evoked action potentials. The biopsy showed pronounced subperineurial edema, macrophage infiltration, and many axons that had been completely demyelinated, some associated with intratubal macrophages. The biopsy unequivocally identified the pathological process as primary demyelination, not axonal degeneration, and was more informative than previous reports of sural nerve biopsies in patients with Guillain-Barre syndrome.

Hall SM, Hughes RAC, Atkinson PF, McColl I, Gale A. Motor nerve biopsy in severe Gulllain-Barre syndrome.

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