Motor-evoked responses in primary lateral sclerosis

✍ Scribed by W. F. Brown; G. C. Ebers; A. J. Hudson; C. E. Pringle; J. Veitch

• Book ID: 102537375
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 336 KB
• Volume: 15
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.880150515

✦ Synopsis

Primary lateral sclerosis (PLS) may be distinguished on the basis of clinical and pathological features from amyotrophic lateral sclerosis (ALS). The former is featured by a much longer clinical course, exclusively upper motor neuron findings, losses of precentral pyramidal neurons, and preservation of anterior horn cells. Electrophysiological studies of 7 PLS cases have shown normal peripheral motor conduction, absent or very delayed motorevoked potentials, the occasional late development of denervation activity in distal muscles, and normal somatosensory-evoked potentials.