Motor benefit from levodopa in spastic quadriplegic cerebral palsy

✍ Scribed by Janice E. Brunstrom; Amy J. Bastian; Michael Wong; Jonathan W. Mink

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 992 KB
• Volume: 47
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/1531-8249(200005)47:5<662::aid-ana18>3.0.co;2-u

✦ Synopsis

Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High-affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi-infarct dementia patients, and 35 age-matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi-infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients.