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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

✍ Scribed by Sean Caenepeel, Lisa Renshaw-Gegg…

Book ID
120698635
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
855 KB
Volume
29
Category
Article
ISSN
1756-9966

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Rectal gastrointestinal stromal tumors associated with a novel germline KIT mutation
✍ Agnieszka Woźniak; Piotr Rutkowski; Raf Sciot; Włodzimierz Ruka; Wanda Michej; M 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 326 KB

## Abstract Somatic, activating mutations of __KIT__ or __PDGFRA__ are early oncogenic events in the majority of sporadic gastrointestinal stromal tumors (GISTs). Also a number of families with GISTs have been described in recent years. The familial GIST syndrome is a rare autosomal dominant disord