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Mortality studies of machining fluid exposure in the automobile industry V: A case-control study of pancreatic cancer

✍ Scribed by Judith A. Bardin; Ellen A. Eisen; Paige E. Tolbert; Marilyn F. Hallock; S. Katharine Hammond; Susan R. Woskie; Thomas J. Smith; Richard R. Monson

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
51 KB
Volume
32
Category
Article
ISSN
0271-3586

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✦ Synopsis

Results are presented from a case-control study of 97 cases of pancreatic cancer nested in a cohort of workers from three automobile manufacturing plants. Risk was examined for lifetime exposure to straight, soluble, and synthetic metalworking fluids, as used in specific machining or grinding operations, as well as for constituents of the fluids. Pancreatic cancer was associated with exposure to synthetic fluids in grinding operations, with an odds ratio of 3.0 (95% CI: 1.2-7.5) among those with more than 1.4 mg/m 3 -years of exposure. We were unable to examine synthetic exposure in the absence of grinding because there was virtually no exposure to synthetics in machining operations in this study population. Although a disproportionately high percent of the cases were black, no black workers had any exposure to synthetic fluids, and no other measured exposure was found to be related to risk. Thus, the previously documented excess risk of pancreatic cancer among blacks in this cohort remains

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