Abstract
Background
Employees engaged in the tanning and finishing of leather are potentially exposed to numerous carcinogens.
Methods
A previous mortality study among 9,352 workers from two chrome tanneries has been updated with the addition of 11 years of vital status and work history followβup and 1,153 new deaths. Ninetyβtwo different causes of death were analyzed using a modified lifeβtable approach. Death rates from both the United States and the states in which the tanneries were located were used as the comparison populations in calculating causeβspecific standardized mortality ratios (SMRs).
Results
The mortality risks from all causes and from all cancers were lower than the expected for the combined cohort. Analyzing the two tanneries separately, no a priori cause of death (i.e., cancer of the lung, pancreas, bladder, kidney, testes, nasal cavity, lymphoma, or softβtissue sarcoma) was shown to be significantly elevated. An exception was lung cancer at one tannery when state death rates were used (SMRβ=β130, Pβ<β0.01). Analyzing by duration of employment, no significant trend in any cause of death at either tannery was revealed.
Conclusions
Some studies have shown elevated risks for various siteβspecific causes of cancer; however, sites in excess are not consistent between studies. The differences may have been due to distinct processes used by the tanneries resulting in varying levels, as well as different types, of exposures. Am. J. Ind. Med. 44:197β206, 2003. Published 2003 WileyβLiss, Inc.