Morroniside cinnamic acid conjugate as an anti-inflammatory agent

✍ Scribed by Yoshinori Takeda; Naomi Tanigawa; Fortunatus Sunghwa; Masayuki Ninomiya; Makoto Hagiwara; Kenji Matsushita; Mamoru Koketsu

• Book ID: 104004567
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 296 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.06.095

✦ Synopsis

A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC 50 = 49.3 lM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC 50 = 88.2 lM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-a-induced E-selectin expression.