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Morphometric and biochemical analysis of adrenal medullary hyperplasia induced by nicotine in rats

✍ Scribed by Urs A. Boelsterli; Luis-M. Cruz-Orive; Gerhard Zbinden

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
429 KB
Volume
56
Category
Article
ISSN
0340-5761

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✦ Synopsis

The administration of nicotine (1 and 4 mg/kg/day, subcutaneously for up to 6 weeks) to male Sprague-Dawley rats first induced a time-and dose-dependent increase in catecholamine (CA) synthesis. This was followed by an increase in endogenous CA levels and in total volume and number of chromaffin cells, as measured by stereological methods on serially sectioned adrenal glands. Thus, continued stimulation of the sympathoadrenal system generated an increase in biosynthetic enzyme activity, and subsequently adrenal medullary hypertrophy and hyperplasia developed as an adaptive reaction. The proposed model is useful for quantifying both biochemically and morphometrically early adrenal changes long before irreversible pathologic alterations are manifested.

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