Morphometric Analysis of Type I Collagen Fibrils in the Osteoid of Osteogenesis Imperfecta
β Scribed by P. Sarathchandra; F. M. Pope; S. Y. Ali
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 785 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1432-0827
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π SIMILAR VOLUMES
## Communicated by Richard G.H. Cotton Mutations in the type I collagen genes COL1A1 and COL1A2 are responsible for the dominantly inherited connective tissue disorder osteogenesis imperfecta (OI). The severity of OI is diverse, ranging from perinatal lethality to a very mild phenotype that is cha
Osteogenesis imperfecta (OI) is a disease characterized by bone malformations caused by mutations in type 1 collagen. 1 Since many of the 338 possible glycine mutations have not been observed in clinical practice, is this due to chance alone? Because only 83 mutations have been reported in 126 patie