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Morphology of early changes in liver carcinogenesis induced by methapyrilene

✍ Scribed by Hildegard M. Reznik-Schüller; William Lijinsky

Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
574 KB
Volume
49
Category
Article
ISSN
0340-5761

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✦ Synopsis

Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal hepatocytes in F344 rats. Administration of [3H]-methapyrilene hydrochloride resulted in a pronounced concentration of bound radioactivity in the periportal hepatocytes, with mitochondria being the principal site of intracellular binding. The nuclei of the liver cells were unlabeled.

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