Morphological transformation of BALB/3T3 cells by various procarcinogens in the presence of a rat liver S-9 activation system

Transformation of BALB3T3 cells caused b

Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: Mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity

✍ Takao Shishido; Shinsuke Uno; Masazumi Kamohara; Takako Tsuneoka-Suzuki; Yoshiyu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 144 KB

CD98 is a 125-kDa glycoprotein (GP125) consisting of an 85-kDa heavy chain (HC) and a 40-kDa light chain (LC), and is highly expressed on the cell surface of activated lymphocytes and various tumor cells. In addition to the regulatory role of CD98HC in L-, y ؉ L-and Xc-amino-acid transport systems,